TABLE I.
Summary of hemodynamic data from 5 WT mice.
| Parameter | Baseline | Iso1 | Iso2.5 |
|---|---|---|---|
| Z0 (dynes-s/cm3) | 9386±489 | 7733±591† | 6315±433‡* |
| Z1 (dynes-s/cm3) | 654±45 | 640±36 | 654±51 |
| ZC (dynes-s/cm3) | 306±30 | 284±20 | 333±27 |
| PWV=ZC/ρ (cm/s) | 281±28 | 261±18 | 306±25 |
| PeakAFV (cm/s) | 111.1±5.8 | 124.2±7.0 | 136.1±6.6‡* |
| MeanAFV (cm/s) | 23.5±0.9 | 27.2±1.6 | 29.4±1.0‡ |
| ABPsys (mmHg) | 97.1±5.4 | 93.1±4.9 | 86.2±2.4‡ |
| ABPdias (mmHg) | 70.1±3.5 | 63.2±3.8† | 53.3±2.2‡ |
| ABPmean (mmHg) | 83.4±4.3 | 78.0±4.3† | 69.1±2.0‡ |
| APP (mmHg) | 27.0±1.9 | 29.9±1.7† | 32.9±2.3‡* |
| HR (beats/min) | 417±21 | 423±20 | 414±28 |
| PkLVP (mmHg) | 102.2±2.9 | 99.2±3.6 | 94.8±3.0‡* |
| LVEDP (mmHg) | 7.1±0.9 | 7.2±0.4 | 6.9±0.8 |
| +dP/dt (mmHg/s) | 9798±1481 | 8154±599 | 7678±218 |
| −dP/dt (mmHg/s) | −13445±3408 | −13209±2905 | −10644±1673 |
| tau (msec) | 7.4±0.9 | 7.5±1.3 | 8.9±0.9 |
Values are mean±SEM; PWV - pulse wave velocity; ρ- blood density ≈ 1.06 g/cm3
†
p=<0.05 Iso1 vs Baseline;
‡
Iso2.5 vs. Baseline;
*
Iso1 vs. Iso2.5