Table 2.

Effects of weight-loss program including orlistat on body composition and metabolism.

Race	African American			Caucasian
Variable	Baseline	3 month	6 month	Baseline	3 month	6 month
Weight (kg)	136.7 ± 1.4	134.2 ± 1.4	135.7 ± 1.4	99.3 ± 1.4	93.5 ± 1.4‡	92.9 ± 1.3†
BMI (kg/m2)	50.3 ± 1.3	48.9 ± 1.3†	49.2 ± 1.3	36.2 ± 1.2	33.5 ± 1.2†	33.2 ± 1.2‡
BMI SD Score	7.7 ± 1.0	7.4 ±1.1*	8.7 ± 1.4	4.5 ± 0.8	3.8 0.5‡	3.4 ± 0.8†
BFM (kg)	68.4 ± 1.4	67.3 ± 1.6	70.1 ± 1.6	45.0 ± 1.4	37.7 ±1.3†	36.3 ± 1.3†
LBM (kg)	66.8 ± 1.3	69.1 ± 1.2	73.5 ± 1.2	53.1 ± 1.3	50.3 ± 1.2	50.6 ± 1.2
WC (cm)	121.8 ± 1.2	122.3 ± 1.2	122.5 ± 1.2	104.3 ± 1.2	97.9 ± 1.1†	96.3 ± 1.1‡
REE (kcal/d)	1923 ± 1.1	1710 ± 1.1†	1790 ± 1.2	2183 ± 1.1	1963 ± 1.1*	2099 ± 1.2
Leptin (ng/mL)	34.7 ± 1.7	29.8 ± 1.8	31.1 ± 1.6	28.5 ± 1.6	18.1 ± 1.6*	18.5 ± 1.8*

^*p < 0.05

^†p < 0.01

^‡p < 0.001 vs. baseline.

Baseline: n=20; 3, 6 month: n=17 Change in variables was adjusted for baseline value. BFM, body fat mass; LBM, lean body mass; WC, waist circumference; REE, resting energy expenditure. Geometric means ± SD are reported except REE values are least squares means adjusted for LBM and BFM. Adjusted REE in African Americans was significantly lower than in Caucasians (p<0.05) at 0 and 3 months.