Table 3.

Causes of Cholestatic Liver Disease

INTRAHEPATIC CHOLESTASIS	EXTRAHEPATIC CHOLESTASIS
Hepatitis: Viral (B,C), Alcoholic	Extrinsic Obstruction
Genetic:	- stones
- Benign recurrent intrahepatic cholestasis	Malignancy
- Progressive familial intrahepatic cholestasis	- Pancreas
- Dubin-Johnson, Rotor’s Syndrome	- Gall bladder
- Drugs and hebal remedies	- Metastatic
Pregnancy	- Cholangiocarcinoma
PBC	- Ampullary cancer
PSC	Pancreatitis
Granulomatous liver disease	Pancreatic pseudocyst
- Infections	Parasitic Infection
- Sarcoidosis	Secondary sclerosis (surgery, chemotherapy)
Infiltrative:
- Amyloidosis
- Lymphoma
Idiopathic Adult Ductopenia
Autoimmune Cholangitis (PSC-like)
Autoimmune Cholangiopathy (PBC-like)
Prolonged TPN
Postoperative state
Sepsis
Malignancy
- Hepatocellular
- Metastatic