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. 2012 Mar 25;5(3):187–194.

Table 3.

Immunohistochemical scores by different authors

Author and score Expression pattern and evaluation
Papotti et al. (2002)  
- negative
+ < 25% of tumor cells positive
++ 25%-50% of tumor cells positive
+++ > 50% of tumor cells positive

Volante et al. (2007) – only for SSTR2A
0 no immunoreactivity
1 only cytoplasmatic immunoreaction, focal or diffuse
2 membrane immunoreaction < 50%
3 membrane immunoreaction > 50%

Volante et al. (2007) - for SSTR 3 and 5
positive > 10% cytoplasmatic staining

Corleto et al. (2009)  
0 no staining
+ mildly positive
++ moderately positive
+++ intensely positive

Miederer et al. (2009) - for SSTR2A
0 negative
1+ mild incomplete membrane reaction
2+ moderate complete membrane reaction
3+ strong complete membrane reaction

Zamora et al. (2010)  
Negative no receptor expression
focally positive < 25% of positive cells with heterogenous pattern
positive > 25% of positive cells with moderate to strong density