Survival of MET fluorescent in situ hybridization (FISH)+ and MET FISH− according to stage, grade, and epidermal growth factor receptor (EGFR) FISH. (A) In stage I-II disease, 20 patients were MET FISH+ and 233 were MET FISH−. Median survival was not reached in MET FISH− and was 33.0 months in MET FISH+. This difference was statistically significant (P = .032). (B) In stage III-IV disease, MET FISH+ patients (n = 28) had shorter survival (20.8 v 22.8 months) than MET FISH− (n = 150). This difference was not statistically significant (P = .3). (C) In grade 1-2 disease, MET FISH+ (n = 23) had shorter survival (28.1 v 48.8 months) than MET FISH− (n = 250). The difference did not reach the statistical significance (P = .1). (D) In grade 3 disease, MET FISH+ (n = 25) had significantly shorter survival (20.8 v 38.1 months) than MET FISH− (n = 131). The difference was statistically significant (P = .03). (E) EGFR FISH negative/MET FISH− (n = 197) had significantly longer survival (55.9 v 22.6 months; P = .0001) than EGFR FISH−/MET FISH+ (n = 15). (F) Among patients EGFR FISH+, survival was longer in MET FISH− (n = 128) than in the 31 patients MET FISH+ (median survival, 42.6 v 28.9 months) even if the difference was not statistically significant (P = .2).