Table 3.

Univariable and Multivariable Analyses on Survival

Variable	Category	Univariable			Multivariable
		HR	95% CI	P	HR	95% CI	P
Sex	Male/female	0.91	0.66 to 1.26	.6	0.87	0.57 to 1.33	.5
Smoking	Smoker/never smoker	1.28	0.81 to 2.04	.3	1.24	0.69 to 2.25	.5*
Histology	Adenocarcinoma†/other	0.97	0.75 to 1.25	.8	1.02	0.76 to 1.38	.9
Grade	I + II/III	0.78	0.60 to 1.01	.06	0.89	0.66 to 1.20	.4
Stage	I + II/III + IV	0.40	0.31 to 0.51	< .0001‡	0.42	0.31 to 0.56	< .0001‡
MET FISH	< 5/≥ 5 copies	0.59	0.41 to 0.85	.005‡	0.66	0.43 to 0.99	.04‡
EGFR FISH	Negative/positive	0.89	0.67 to 1.17	.34	1.02	0.74 to 1.39	.9

Abbreviations: HR, hazard ratio; FISH, fluorescent in situ hybridization; EGFR, epidermal growth factor receptor.

^*Sex, smoking status, histology, grade, and EGFR FISH variables were removed from the model at the last step of multivariable analysis.

^†Adenocarcinoma category also included bronchioloalveolar histology.

^‡Statistically significant.