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. 2012 Apr 3;106(9):1512–1519. doi: 10.1038/bjc.2012.126

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Copyright © 2012 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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TGF-β1 might have important roles in the inter-conversion and homoeostasis between NSCCs and CSCs via activating EMT. (A) Exogenous supplement of TGF-β1 accelerates transition of CSCs from NSCCs (mean±s.d., n=3; *P=0.02982), whereas SB431542 inhibits the transition (mean±s.d., n=3; *P=0.02395); TGF-β1- and SB431542-treated unsorted SW620 cells showed a significant difference in CSC proportion (mean±s.d., I=3; *P=0.03757). (B) Expressions of E-cadherin in purified NSCCs with or without TGF-β1 and SB431542. (C) Expressions of Vimentin in purified NSCCs with or without TGF-β1 and SB43154. Data was detected through FACS at day 8 post inoculation.