Table 3. Hazard ratios (HRs) for death and their 95% confidence intervals (CIs) according to partner's vital status and time between diagnosis, death and death of partner among 21 213 women with breast cancer diagnosed in 1994–2006, Denmark.
|
Crude
a
|
Adjusted HR
b
|
Adjusted HR
c
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Person years | Events | HR d | (95% CI) | HR d | (95% CI) | HR d | (95% CI) | |
| All-cause mortality | |||||||||
| Exposure before diagnosis | |||||||||
| Time from bereavement to diagnosis (years) | |||||||||
| [0–1] | 228 | 1610 | 76 | 1.17 | (0.93, 1.48) | 1.15 | (0.91, 1.44) | 1.04 | (0.82, 1.34) |
| ]1–2] | 195 | 1391 | 65 | 1.14 | (0.89, 1.46) | 1.04 | (0.81, 1.34) | 1.05 | (0.80, 1.38) |
| ]2–4] | 339 | 2215 | 102 | 1.11 | (0.91, 1.36) | 1.04 | (0.85, 1.26) | 1.19 | (0.96, 1.47) |
| Exposure after diagnosis | |||||||||
| Time from bereavement to death (years) | |||||||||
| [0–1] | 647 | 5768 | 173 | 1.20 | (0.98, 1.48) | 1.16 | (0.95, 1.43) | 1.11 | (0.89, 1.39) |
| [1–5] | 766 | 7237 | 156 | 1.11 | (0.97, 1.28) | 1.08 | (0.94, 1.23) | 1.09 | (0.94, 1.26) |
| >5 | 846 | 10142 | 111 | 1.07 | (0.88, 1.31) | 1.04 | (0.85, 1.27) | 1.08 | (0.87, 1.34) |
| Recurrence | |||||||||
| Exposure before diagnosis | |||||||||
| Time from bereavement to diagnosis (years) | |||||||||
| [0–1] | 228 | 904 | 15 | 0.66 | (0.40, 1.10) | 0.66 | (0.39, 1.09) | 0.57 | (0.32, 1.01) |
| [1–2] | 195 | 800 | 14 | 0.71 | (0.42, 1.20) | 0.69 | (0.41, 1.17) | 0.74 | (0.42, 1.32) |
| [2–4] | 339 | 1135 | 30 | 1.05 | (0.73, 1.51) | 1.03 | (0.72, 1.49) | 1.11 | (0.74, 1.65) |
| Exposure after diagnosis | |||||||||
| Time from bereavement to death (years) | |||||||||
| [0–1] | 467 | 2439 | 48 | 0.90 | (0.61, 1.34) | 0.90 | (0.60, 1.33) | 0.73 | (0.46, 1.17) |
| [1–5] | 412 | 2837 | 28 | 1.01 | (0.76, 1.34) | 1.00 | (0.75, 1.33) | 1.01 | (0.75, 1.36) |
| >5 | 260 | 2306 | 9 | 1.02 | (0.52, 2.00) | 1.02 | (0.52, 2.00) | 1.16 | (0.57, 2.37) |
a
Stratified by age at diagnosis in 1-year intervals.
b
Adjusted for the highest-attained educational level, disposable income and stratified by age at diagnosis in 1-year intervals.
c
Adjusted for the highest-attained educational level, disposable income, period of diagnosis, comorbidity, tumour size, no. of tumour-positive lymph-nodes, hormone receptor status, malignancy grade and stratified by age at diagnosis in 1-year intervals (N=19 186) (defined in Table 1).
d
The reference category (HR=1) are not experiencing the death of a cohabiting partner in the given year-interval.