Table 1. The distribution of children by deprivation quintile, age group, immunophenotype, and pre-treatment blood counts, within each clinical trial period and overall.
| Clinical trial | UKALL VIII | UKALL X | UKALL XI | ALL 97/99 | All trials |
|---|---|---|---|---|---|
| Start | September 1980 | January 1985 | October 1990 | March 1997 | September 1980 |
| End | December 1984 | September 1990 | February 1997 | November 2002 | November 2002 |
| Number of children | 703 | 1395 | 1851 | 1652 | 5601 |
| Deprivation quintile | |||||
| 1 (affluent) | 149 (21%) | 270 (19%) | 390 (21%) | 358 (22%) | 1167 (21%) |
| 2 | 149 (21%) | 295 (21%) | 402 (22%) | 329 (20%) | 1175 (21%) |
| 3 | 142 (20%) | 277 (20%) | 365 (20%) | 330 (20%) | 1114 (20%) |
| 4 | 141 (20%) | 280 (20%) | 365 (20%) | 347 (21%) | 1133 (20%) |
| 5 (deprived) | 122 (17%) | 273 (20%) | 329 (18%) | 288 (17%) | 1012 (18%) |
| Age at diagnosis (years) | |||||
| 1–4 | 387 (55%) | 823 (59%) | 1079 (58%) | 909 (55%) | 3198 (57%) |
| 5–9 | 202 (29%) | 406 (29%) | 533 (29%) | 506 (31%) | 1647 (29%) |
| 10–13 | 114 (16%) | 166 (12%) | 239 (13%) | 237 (14%) | 756 (13%) |
| Immunophenotype | |||||
| B-precursor | 561 (90%) | 1227 (91%) | 1486 (89%) | 1456 (90%) | 4730 (90%) |
| T-precursor | 61 (10%) | 116 (9%) | 193 (11%) | 168 (10%) | 538 (10%) |
| Unknown | 81 | 52 | 172 | 28 | 333 |
| Risk of pallor | |||||
| No (haemoglobin ⩾5 g dl−1) | 551 (80%) | 1060 (77%) | 1396 (76%) | 1295 (79%) | 4302 (78%) |
| Yes (haemoglobin<5 g dl−1) | 140 (20%) | 318 (23%) | 434 (24%) | 341 (21%) | 1233 (22%) |
| Unknown | 12 | 17 | 21 | 16 | 66 |
| Risk of bleeding | |||||
| No (platelets ⩾20 × 109 l−1) | 541 (78%) | 1090 (79%) | 1391 (76%) | 1227 (75%) | 4249 (77%) |
| Yes (platelets<20 × 109 l−1) | 157 (22%) | 286 (21%) | 439 (24%) | 410 (25%) | 1292 (23%) |
| Unknown | 5 | 19 | 21 | 15 | 60 |
| Risk of sepsis | |||||
| No (neutrophils ⩾0.5 × 109 l−1) | 358 (52%) | 749 (56%) | — | — | 1107 (55%) |
| Yes (neutrophils<0.5 × 109 l−1) | 324 (48%) | 596 (44%) | — | — | 920 (45%) |
| Unknown | 21 | 50 | 1851 | 1652 | 3574 |
| Risk of non-diagnosis a | |||||
| No | 492 (73%) | 1027 (77%) | — | — | 1519 (76%) |
| Yesb | 179 (27%) | 311 (23%) | — | — | 490 (24%) |
| Unknown | 32 | 57 | 1851 | 1652 | 3592 |
a
Sepsis without pallor or bleeding.
b
Neutrophils <0.5 × 109 l−1, haemoglobin ⩾5 g dl−1, and platelets ⩾20 × 109 l−1. United Kingdom Medical Research Council clinical trial participants, resident in Great Britain, aged 1–13 years at diagnosis of acute lymphoblastic leukaemia 1980–2002.