Superimposed unbound form (loops in red, PDB code 6Q21, chain D) and bound form (loops in blue, PDB code 1WQ1 chain R) of H-Ras. Figure generated using PyMOL (www.pymol.org). loop 1 (switch I: residue number 30–38), loop 2 (switch II: residue number 60–67), loop 3 (residue number 105–110), loop 4 (residue number 117–126) and loop 5 (residue number 145–151. The residue numbers listed refer to the numbering of the unbound structure.