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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: JACC Cardiovasc Interv. 2011 Oct;4(10):1057–1066. doi: 10.1016/j.jcin.2011.05.025

Figure 2. Differentiation of bone marrow-derived stem cells.

Figure 2

Previously, CD34-positive cells were believed to be committed population of EPCs, however further study demonstrated that the CD34 surface antigen actually identifies undifferentiated bone marrow-derived stem cells that have the ability differentiate into EPC and SMPCs. Ischemic conditions signal differentiation toward EPC phenotypes in order to promote reendothelialization. Inflammatory conditions signal differentiation toward SMPC phenotypes that promote neointimal proliferation.