Table 4. Adverse events (N, %).
|
DS arm
|
D arm
|
||||
|---|---|---|---|---|---|
| Grade 1–2 | Grade 3–4 | Grade 1–2 | Grade 3–4 | P -value | |
| Anaemia | 45 (80.4) | 6 (10.7) | 41 (83.7) | 5 (10.2) | 0.856 |
| Leukopenia | 13 (23.2) | 12 (21.4) | 5 (10.2) | 7 (14.3) | 0.084 |
| Neutropenia | 8 (14.3) | 18 (32.1) | 4 (8.2) | 10 (20.4) | 0.169 |
| Thrombocytopenia | 26 (46.4) | 2 (3.6) | 13 (26.5) | 2 (4.1) | 0.107 |
| Febrile neutropenia | N/A | 15 (26.8) | N/A | 8 (16.3) | 0.196 |
| Nausea | 19 (33.9) | none | 13 (26.5) | none | 0.411 |
| Vomiting | 9 (16.1) | none | 6 (12.2) | none | 0.576 |
| Stomatitis | 29 (51.8) | none | 7 (14.3) | none | <0.001 |
| Diarrhoea | 14 (25.0) | 6 (10.7) | 6 (12.2) | 1 (2.0) | 0.033 |
| Hand–foot syndrome | 27 (48.2) | 3 (5.4) | 10 (20.4) | none | 0.002 |
| Neuropathy | 37 (66.1) | none | 28 (57.1) | none | 0.347 |
| Myalgia | 8 (14.3) | none | 11 (22.4) | 1 (2.0) | 0.295 |
Abbreviations: D=docetaxel monotherapy; DS=docetaxel+sunitinib.