Table 3.
Details of the peptides observed in block 388 of the NS3 protein.
| # | Peptide | Frequency | Acc. frequency | Bits | HLA binding (nM) | Serotypes containing peptide (%) |
|---|---|---|---|---|---|---|
| 1 | KTFDTEYQK | 65.03 | 65.03 | 0.84 | A*03:01(59.69); A*11:01(5.41) | DENV1(99.67) DENV3(99.32) |
| 2 | KTFDSEYVK | 28.69 | 93.72 | 0.37 | A*03:01(51.48); A*11:01(7.19) | DENV1(0.08) DENV2(92.64) |
| 3 | KTFDTEYPK | 3.82 | 97.54 | 0.05 | A*03:01(26.17); A*11:01(3.35) | DENV4(100) |
| 4 | KTFDSEYIK | 1.18 | 98.71 | 0.02 | A*03:01(71.55); A*11:01(8.59) | DENV2(4.19) |
| 5 | KTFDTEYTK | 0.29 | 99.01 | 0.00 | A*03:01(37.45); A*11:01(4.65) | DENV2(0.95) |
| 6 | KTFDSEYAK | 0.29 | 99.30 | 0.00 | Not predicted | DENV2(0.95) |
| 7 | KTFDTEYIK | 0.26 | 99.56 | 0.00 | Not predicted | DENV2(0.90) |
| 8 | RTFDTEYQK | 0.11 | 99.67 | 0.00 | Not predicted | DENV1(0.25) |
| 9 | KTFETEYQK | 0.11 | 99.78 | 0.00 | Not predicted | DENV3(0.17) |
| 10 | KTFDAEYVK | 0.07 | 99.85 | 0.00 | Not predicted | DENV2(0.25) |
| 11 | KTFNTEYQK | 0.07 | 99.93 | 0.00 | Not predicted | DENV3(0.34) |
| 12 | KTFDTEYQR | 0.04 | 99.96 | 0.00 | Not predicted | DENV3(0.17) |
| 13 | KTFDFEYIK | 0.04 | 100 | 0.00 | Not predicted | DENV2(0.12) |
Peptide 1 (KTFDTEYQK) is a known ligand for HLA-03, -11, and -31. Furthermore, peptides 2–5 are predicted to have similar binding affinity to peptide 1 for HLA-A3 supertype alleles using MULTIPRED2 (Zhang et al., 2011).