Table 3.

Oncogenic phenotypes mediated by Axl and Mer in solid tumors.

Phenotype	Glioblastoma Multiforme	Non-small cell lung cancer	Breast Cancer
In vitro proliferation	•	••	•
Anchorage-independent growth	••		•
Xenograft growth	•	•	•
Survival signaling (PI3K, MAPK)	••
Apoptosis	••	••
Autophagy	••
Migration	•	•	•
Invasion	•	•	•
EMT			•
Metastasis			•
Angiogenesis*			•
Chemosensitivity	••	••	•

^•indicates Axl mediated phenotype; • indicates Mermediated phenotype.

^*Although angiogenesis has only been specifically evaluated in animal models of breast cancer, this phenotype is due to Axl expression in endothelial cells and therefore may be applicable to all solid tumors.