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. 2011 Dec 7;2:64. doi: 10.3389/fimmu.2011.00064

Figure 1.

Figure 1

Structure of SLO. Fluorescent immunohistochemistry (left) and cartoons (right) illustrate the structure and cellular content of spleen (A,B) and LN (C,D). (A) The outer capsule of the spleen surrounds the red pulp, with the sinuses and white pulp embedded within. ER-TR7 fibers form a network supporting the red pulp, and FRC line the borders between the red and white pulp. A central arteriole empties into the white pulp. (B) In the white pulp, T cells populate the PALS leading into the B cell follicles. DC line the marginal sinus, enclosed by the marginal zone. (C) In the LN, the efferent lymphatics empty into the medullary sinus and travel through the medullary cords. Lymphocytes enter through the HEV, which seed the LN. (D) B cells, FDC, and macrophages lay in the cortex. The paracortex contains T cells and DC. Antigen presentation and T cell priming occur at the cortical ridge areas between B and T cell zones supported by FRC.