Skip to main content

View full-text article in PMC

. 2011 Dec 7;2:64. doi: 10.3389/fimmu.2011.00064

Table 2.

Treg in lymphoid organs.

Primary lymphoid organ	Thymus	Treg development	Involved cells: Medullary epithelial cells expressing Aire, TSLP Cortical DCs expressing TSLP Recirculated immature DC Involved molecules: CD28, IL-2, TSLP, CD154, GITR, Stat5, TGFβ
	Bone marrow	Treg recruitment	CXCR4/CXCL12 interaction
		Treg role	Providing immune-privileged sites for HSPC Mobilized to peripheral tissue (i.e., tumor) via CCR4/CCL2 interaction
Secondary lymphoid organ	Spleen	Treg generation	Involved cells: Regulatory or immature DC from peripheral tissues F4/80^hiMac-1^low macrophages in red pulp
	LN	Treg generation	Involved cells: DC migrated via afferent lymphatics pDC migrated via HEV
		Treg role	Treg migrated from peripheral tissues more potent than LN-resident Tregs Inhibition of T cell priming and activation by Treg–DC interaction Inhibition of T_FH cells/B cells/germinal center reaction by F_Treg Treg in peripheral tissues inhibit DCmigration to LN
Tertiary lymphoid organ		Treg detected; role not certain