Table 3.
Dendritic cell function in lymphoid organs.
| Name | Subset | Phenotype | Location | Function |
|
|---|---|---|---|---|---|
| Activated or mature | In the steady state or tolerance | ||||
| Lymphoid organ-resident | CD8+ | CD11c+CD11b−CD8+CD4− (also CD103+CD207+ subset) | Spleen, LN and thymus | Promote cytotoxic T cell responses | CD8+ T cell tolerance Induce Treg T cell suppression by IOD CD4+ T cell hyporesponsiveness (Mellor et al., 2005; Dudziak et al., 2007; Yamazaki et al., 2008; Dominguez and Ardavin, 2010; Johnson et al., 2010; Shortman and Heath, 2010) |
| CD4+ | CD11c+CD11b+CD8−CD4+ | Spleen and LN | Promote CD4+ T cell responses | CD4+ T cell tolerance Expansion of Treg populations (Dudziak et al., 2007; Dominguez and Ardavin, 2010; Shortman and Heath, 2010) |
|
| CD8−CD4− | CD11c+CD8−CD4− (CD11b+ and CD11b− subsets) | Spleen and LN | |||
| Migratory | CCR7+ | LC(CD11c+ CD207+CD103−) CD103+CD11c+ (CD11b+CD103+) CD103+CD11b+(CD11c+CD11b−CD103+) |
LN | Transport the pathogen to the draining LN and promote T cell responses Up-regulate homing receptors of activated T cells | Carry PTA from periphery into LN CD8+ T cell tolerance Induce Treg (Varol et al., 2009; Liu and Nussenzweig, 2010) |
| CD11b+? (CD11c+CD11b+CD103−) | Not clear | Not clear | Not clear | ||
| Plasmacytoid | CD11cmid CD11b−CD8± CD4+Gr-1+ (produce type I IFNs) | Thymus, bone marrow, and secondary lymphoid tissue | Anti-viral immunity | Induce Tregs Alloimmune tolerance (Ochando et al., 2006; Gilliet et al., 2008; Manches et al., 2008; Swiecki and Colonna, 2010) |
|
| Inflammatory (TIP and monocyte) | CD11c+CD11b+Ly6C+ (produce TNF and express iNOS) | Inflammatory lesions | Induction of adaptive immunity | Tezuka et al. (2007), Kool et al. (2008), Dominguez and Ardavin (2010) | |
“?” indicates that these cells may express CD11b.