Table 1.
Key structures of the SPM: resolvins, protectins, and maresins.
RvE1 | Resolvin E1 (5S,12R,18R-trihydroxy-eicosa-6Z,8E,10E,14Z,16E-pentaenoic acid) |
RvE2 | Resolvin E2 (5S,18R-dihydroxy-eicosapentaenoic acid) |
PD1/NPD1 | Protectin D1/neuroprotectin D1 (10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid) |
RvD1 | Resolvin D1 (7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid) |
RvD2 | Resolvin D2 (7S,16R,17S-trihydroxydocosa-4Z,8E,10Z,12E,14E,19Z-hexaenoic acid) |
RvD3 | Resolvin D3 (4S,11,17S-trihydroxydocosa-5,7E,9E,13Z,15E,19Z-hexaenoic acid) |
RvD4 | Resolvin D4 (4S,5,17S-trihydroxydocosa-6E,8E,10Z,13Z,15E,19Z-hexaenoic acid) |
RvD5 | Resolvin D5 (7S,17S-dihydroxy-docosa-4Z,8E,10Z,13Z,15E,19Z-hexaenoic acid) |
MaR1 | Maresin 1 (7,14-dihydroxy-docosa-4Z,8,10,12,16Z,19Z-hexaenoic acid) |
Complete structures of the key SPM are reported and total organic synthesis was recently reviewed in Serhan and Petasis (2011).