Table 1.

Phosphatidylserine, bridge molecules, and receptors for apoptotic cells including those known to be modulated by nuclear receptor signaling.

Ligand on apoptotic cell	Bridge molecules	Efferocytic receptor
PS	None	BAI1
PS	None	TIM1, TIM3, TIM4
PS	None	Stabilin-1, stabilin-2
PS	None	Receptor for advanced glycation end products (RAGE)
PS; oxidized PS	C1q*,**, MBL	Calreticulin/LRP (CD91)*
PS; oxidized PS	Gas6**, protein S	Mer*,**∧, Axl*,**, Tyro3
PS; oxidized PS	MFG-E8*,**	αVβ3/5 integrins
	Thrombospondin**	CD36*
PS; oxidized PS	Collectins (SP-A, SP-D)	LRP (CD91)*

Ligands, bridge molecules, and receptors are more comprehensively discussed in reference (Henson and Bratton, 2009) and references therein.

*Expression regulated by PPAR-γ (Berry et al., 2007; Majai et al., 2007; Roszer et al., 2011).

**Expression regulated by PPAR-δ (Mukundan et al., 2009).

^∧Expression regulated by LXR (A-Gonzalez et al., 2009).