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Multivesicular bodies (MVBs) at the core of antigen processing with the help of the macroautophagic molecular machinery. Macroautophagy and/or its molecular machinery support antigen processing via three main pathways. They transport cytoplasmic material into MHC class II loading compartments (MIICs), assist phagosome fusion with MIICs, and might allow for the release of antigen for efficient cross-presentation.
