Table 2.

Anti-correlated and positively correlated mRNA/microRNA pairs in the tumour and/or the normal samples

microRNA	mRNA	normal	tumour	MicroRNA Regulation in tumour vs. normal	Gene Regulation in tumour vs. normal	P-value
hsa-miR-140-3p	RAD51AP1	-	-	Down	Up	0.021
hsa-miR-139-5p	DNAH9	-	None	Down	Down	0.036
hsa-miR-139-5p	TOP2A	-	None	Down	Up	0.009
hsa-miR-140-3p	GCLC	-	None	Down	Down	0.036
hsa-miR-145	E2F3	-	none	Down	Up	0.009
hsa-miR-139-5p	E2F3	-	none	Down	Up	0.009
hsa-miR-96	FAM64A	-	none	Up	Up	0.002
hsa-miR-590-5p	E2F3	+	-	Up	Up	0.036
hsa-miR-34c-5p	E2F3	+	-	Down	Up	0.036
hsa-miR-16	CDC25C	+	+	Up	Up	0.0
hsa-miR-18a	GINS1	+	+	Up	Up	0.036
hsa-miR-18b	GINS1	+	+	Up	Up	0.036
hsa-miR-590-5p	TOP2A	+	none	Up	Up	0.036
hsa-miR-590-5p	RAD51AP1	+	none	Up	Up	0.021
hsa-miR-18a	RAD51AP1	+	none	Up	Up	0.021
hsa-miR-18a	GCLC	+	none	Up	Down	0.036
hsa-miR-15b	E2F3	+	none	Up	Up	0.021
hsa-miR-18a	NUSAP1	+	none	Up	Up	0.036
hsa-miR-590-5p	GINS1	+	none	Up	Up	0.036

b) This Table lists the 19 mRNA/microRNA regulatory pairs found in normal ovary samples. The microRNA shown are also differentially expressed in tumour samples compared with normal, exhibit seed sequence complementarity in the gene shown, and are significantly anti-correlated (red) or positively correlated (blue) with the corresponding mRNA in the normal samples. The third and fourth columns show the type of correlation (if present) within normal and tumour samples respectively. A "+" symbol represents a positive correlation, while "-" represents an anti-correlation, and "none" represents no significant correlation across the samples