Figure 3. Lack of correlation between age and INS promoter methylation in T1D patients (green) and Controls (red).

Only CpG -180 methylation showed a slight downward trend with age (r = 0.09, p = 0.01). The figure also shows the distribution of individual methylation values, and the differences between T1D and control subjects for CpGs -19, -135, -180, and -234.