Figure 1.

The IFNAR signaling promotes L. amazonensis infection in mice. (A) IFNAR^−/− mice developed smaller lesions that contained lower parasite loads than did wild-type controls. (B) The infection-promoting effect of IFN-a was detectable at 3 days post-infection. The lack of IFNAR signaling restrained parasite infection at early stages of the infection. Adapted from Xin et al. (2010).