Table 2. Effect of haplotype on triglycerides, LDL-cholesterol and HDL-cholesterol in 411 normal to overweight males (Cohort #1) on eucaloric diets.
| Triglyceride, mg/dl (SD) | LDL Cholesterol, mg/dl (SD) | HDL Cholesterol, mg/dl (SD) | |||||||
| Haplotype | Non-Carrier | Carrier | P-Value | Non-Carrier | Carrier | P-Value | Non-Carrier | Carrier | P-Value |
| H1 | |||||||||
| Sample Size | 241 | 170 | 241 | 170 | 241 | 170 | |||
| LF | 137.4 (100.2) | 145.5 (91.4) | 0.81 | 118.0 (32.7) | 109.6 (30.8) | 0.007 | 40.9 (9.0) | 39.2 (9.7) | 0.29 |
| HF | 112.3 (99.7) | 108.2 (72.9) | 0.19 | 129.3 (35.1) | 121.4 (34.8) | 0.02 | 47.2 (10.9) | 45.7 (12.3) | 0.65 |
| Difference | −25.1 (61.7) | −37.4 (65.7) | 0.09 | 11.3 (19.5) | 11.8 (22.2) | 0.72 | 6.3 (5.5) | 6.5 (6.0) | 0.45 |
| H2 | |||||||||
| Sample Size | 191 | 220 | 191 | 220 | 191 | 220 | |||
| LF | 146.3 (107.3) | 135.9 (86.3) | 0.67 | 112.7 (32.4) | 116.1 (32.0) | 0.19 | 39.7 (9.2) | 40.6 (9.4) | 0.51 |
| HF | 121.0 (117.2) | 101.6 (54.0) | 0.21 | 122.7 (34.1) | 128.9 (35.8) | 0.04 | 46.0 (11.8) | 47.1 (11.2) | 0.50 |
| Difference | −25.3 (67.9) | −34.3 (59.4) | 0.20 | 10.0 (21.1) | 12.8 (20.2) | 0.10 | 6.3 (5.8) | 6.5 (5.6) | 0.77 |
| H3 | |||||||||
| Sample Size | 284 | 127 | 284 | 127 | 284 | 127 | |||
| LF | 143.6 (95.6) | 134.5 (99.0) | 0.14 | 113.8 (31.1) | 116.2 (34.5) | 0.60 | 40.1 (9.4) | 40.5 (9.2) | 0.77 |
| HF | 111.6 (94.6) | 108.3 (77.5) | 0.42 | 126.4 (34.3) | 125.2 (37.1) | 0.56 | 46 (11.5) | 47.8 (11.4) | 0.16 |
| Difference | −31.9 (65.0) | −26.2 (60.4) | 0.58 | 12.6 (20.5) | 9.0 (20.7) | 0.05 | 6.0 (5.7) | 7.3 (5.6) | 0.03 |
| H4 | |||||||||
| Sample Size | 303 | 108 | 303 | 108 | 303 | 108 | |||
| LF | 139.9 (91.4) | 143.2 (110.4) | 0.97 | 114.4 (32.8) | 115.0 (30.3) | 0.65 | 39.8 (9.4) | 41.2 (9.3) | 0.20 |
| HF | 104.6 (62.2) | 127.4 (139.9) | 0.11 | 126.9 (35.8) | 123.7 (33.2) | 0.13 | 46.4 (11.2) | 47.0 (12.2) | 0.76 |
| Difference | −35.3 (60.4) | −15.8 (70.2) | 0.005 | 12.5 (21.0) | 8.7 (19.5) | 0.06 | 6.6 (5.6) | 5.8 (6.0) | 0.17 |
| H5 | |||||||||
| Sample Size | 328 | 63 | 328 | 63 | 328 | 63 | |||
| LF | 142.0 (98.2) | 133.7 (88.2) | 0.60 | 113.7 (31.7) | 119.2 (34.2) | 0.22 | 40.2 (9.5) | 40.2 (8.6) | 0.56 |
| HF | 112.7 (94.1) | 98.8 (57.7) | 0.49 | 124.9 (35.1) | 132.3 (35.2) | 0.14 | 46.7 (11.6) | 46.0 (10.8) | 0.27 |
| Difference | −29.3 (65.7) | −34.9 (50.4) | 0.44 | 11.2 (20.4) | 13.1 (21.9) | 0.56 | 6.5 (5.7) | 5.7 (5.4) | 0.23 |
Abbreviations: LF, low fat diet; HF, high fat diet.
P-values are presented after adjusting for age and baseline BMI; statistical significance level established at α = 0.01.