Table 3. Effect of haplotype on triglycerides, LDL-cholesterol and HDL-cholesterol in 71 normal to overweight females (cohort #2) on eucaloric diet.
| Triglyceride, mg/dl (SD) | LDL Cholesterol, mg/dl (SD) | HDL Cholesterol, mg/dl (SD) | |||||||
| Haplotype | Non-Carrier | Carrier | P-Value | Non-Carrier | Carrier | P-Value | Non-Carrier | Carrier | P-Value |
| H1 | |||||||||
| Sample Size | 42 | 29 | 42 | 29 | 42 | 29 | |||
| LF | 93.5 (47.5) | 105.0 (47.4) | 0.18 | 104.5 (25.5) | 105.8 (39.7) | 0.91 | 48.3 (9.8) | 50.9 (8.8) | 0.26 |
| HF | 74.1 (37.1) | 90.2 (52.0) | 0.08 | 110.5 (28.3) | 108.7 (30.6) | 0.82 | 60.5 (11.5) | 59.9 (11.2) | 0.74 |
| Difference | −19.4 (32.7) | −14.8 (36.3) | 0.53 | 6.1 (15.7) | 2.9 (18.8) | 0.56 | 12.2 (8.1) | 9.0 (9.2) | 0.14 |
| H2 | |||||||||
| Sample Size | 42 | 29 | 42 | 29 | 42 | 29 | |||
| LF | 100.9 (54.1) | 94.3 (36.4) | 0.75 | 104 (34.5) | 106.5 (28.0) | 0.71 | 49.5 (8.6) | 49.2 (10.8) | 0.89 |
| HF | 86.5 (51.9) | 72.3 (28.4) | 0.31 | 108.7 (28.5) | 111.4 (30.4) | 0.68 | 59.8 (10.1) | 61 (12.9) | 0.68 |
| Difference | −14.4 (35.5) | −22.0 (32.0) | 0.37 | 4.7 (15.0) | 4.9 (19.8) | 0.97 | 10.3 (7.7) | 11.7 (10.0) | 0.52 |
| H3 | |||||||||
| Sample Size | 35 | 36 | 35 | 36 | 35 | 36 | |||
| LF | 107.3 (54.9) | 89.4 (37.7) | 0.61 | 108.1 (37.7) | 102 (25.0) | 0.93 | 49.8 (10.9) | 49.0 (8.0) | 0.13 |
| HF | 88.9 (53.2) | 72.7 (32.0) | 0.95 | 108.9 (32.4) | 110.6 (25.9) | 0.42 | 57.7 (10.9) | 62.8 (11.2) | 0.33 |
| Difference | −18.4 (32.1) | −16.7 (36.3) | 0.60 | 0.8 (19.2) | 8.6 (13.8) | 0.11 | 7.9 (6.2) | 13.8 (9.7) | 0.007 |
| H4 | |||||||||
| Sample Size | 51 | 20 | 51 | 20 | 51 | 20 | |||
| LF | 91.0 (35.2) | 116.5 (67.5) | 0.81 | 101.5 (26.7) | 113.9 (41.7) | 0.55 | 50.1 (9.3) | 47.6 (9.8) | 0.78 |
| HF | 71.2 (27.5) | 104.9 (65.9) | 0.58 | 106.8 (26.1) | 117.4 (35.2) | 0.44 | 62 (11.6) | 55.8 (9.4) | 0.37 |
| Difference | −19.8 (33.2) | −11.7 (36.3) | 0.57 | 5.3 (15.2) | 3.5 (21.3) | 0.77 | 12 (9.7) | 8.2 (4.3) | 0.20 |
| H5 | |||||||||
| Sample Size | 68 | 3 | 68 | 3 | 68 | 3 | |||
| LF | 97.6 (47.3) | 112.7 (60.9) | 0.33 | 105.3 (31.2) | 98 (52.4) | 0.97 | 49.4 (9.5) | 48.3 (10.1) | 0.54 |
| HF | 81.1 (45.0) | 71.7 (14.4) | 0.61 | 110.2 (29.0) | 101.7 (37.1) | 0.78 | 60.4 (11.4) | 57.7 (9.0) | 0.36 |
| Difference | −16.5 (33.5) | −41.0 (47.1) | 0.25 | 4.8 (17.2) | 3.7 (15.5) | 0.58 | 11.0 (8.9) | 9.3 (1.2) | 0.68 |
Abbreviations: LF, low fat diet; HF, high fat diet.
P-values are presented after adjusting for age and baseline BMI; statistical significance level established at α = 0.01.