Figure 2. Two major patterns of alterations in intraneuronal Aβ accumulation.

Graphs show a high percentage of neurons with strong cytoplasmic immunoreactivity (mAb 4G8) in the amygdala, thalamus and Purkinje cells in subjects diagnosed with dup(15) autism (D15), a lower percentage in idiopathic autism (IA) subjects, and a low percentage in control subjects. In contrast, the characteristic feature of pyramidal neurons in the frontal, temporal and occipital cortex is a low percentage of neurons with strong Aβ immunoreactivity, whereas the total percentage of Aβ-positive neurons is significantly higher in the dup(15) group than in the idiopathic autism group or in control subjects. Differences in Aβ immunoreactivity in the dup(15) autism vs. control cohort, the idiopathic autism vs. control group, and the dup(15) autism vs. idiopathic autism are significant (p<0.0001).