Figure 4. Alignment of COOH-terminal region of the insect RyR isoforms.

Identical amino acids are shown in black boxes and similar amino acids are highlighted in gray boxes. Gaps have been introduced to permit alignment. Asterisks below the alignment indicate the position of residues discussed in the text (E⁴¹³⁴, I⁴⁹⁴⁶, R⁴⁹⁶², and D⁴⁹⁶⁶ of CmRyR). Triangles below the alignment indicate unique residues (N⁴⁹²², N⁴⁹²⁴, N⁴⁹³⁵, L⁴⁹⁵⁰, L⁴⁹⁸¹, N⁵⁰¹³ and T⁵⁰⁶⁴ of CmRyR) in the lepidopteran homologues. Abbreviations and GenBank entries for the RyR isoforms are described in Figure 2.