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. 2012 May 2;7(5):e35672. doi: 10.1371/journal.pone.0035672

Figure 5. TGIF1 genetic deficiency is not associated with modifications of radiation-induced TGF-β pathway-related molecular profile in vivo.

Figure 5

mRNA levels of (A) TGF-β signaling-related genes and (B) TGF-β/Smad target genes in TGIF1+/+, TGIF1+/− and TGIF1−/− mice 3 days after 19 Gy localized small intestinal irradiation were determined by real time PCR. mRNA level of 18S was used as housekeeping gene and value 1 was assigned to sham-operated TGIF1+/+ animals. Results are the mean ± SEM with 8 to 10 mice per group. *P<0.05 vs TGIF1+/+ sham mice. #P<0.05 vs TGIF1+/+ irradiated mice. No significant difference was obtained between TGIF1+/+, TGIF1+/− and TGIF1−/− sham-irradiated animals.