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. 2012 May 2;7(5):e35897. doi: 10.1371/journal.pone.0035897

Figure 5. Detection of a long conserved haplotype around SDHD gene in two paragangliomas.

Figure 5

(A) LOH analysis revealed 10 chromosome arms with LOH frequency >20% in our set of 30 pheochromocytomas and paragangliomas (top). These regions were analyzed using FounderTracker to detect conserved haplotypes, revealing a single significant region on chromosome arm 11q (bottom). (B) Visualization of the significant region identified on chromosome 11 with the Integrative Genomics Viewer [44]. The IBD score is represented as a blue line above tumor haplotypes. Haplotypes are represented as series of blue and yellow vertical lines, corresponding to SNPs with respectively “A” and “B” genotype, according to Illumina nomenclature. The significant region detected by FounderTracker corresponds to the long haplotype that is identical in tumors HS_048 and HS_158, and results in a high IBD score for this segment. This region contains 32 genes, including SDHD (indicated in red).