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(A) Structure of protein FYVE domain of the RUN and FYVE domain containing protein 1; Zn atoms are shown in red and coordinating cysteins in yellow (PDB code 2yw8). (B) Homodimer of EEA1’s C-terminal FYVE domain bound to inositol-1,3-diphosphate (PDB code 1joc). The picture was prepared using the program VMD (Humphrey et al., 1996).
