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Human B- and T-cell differentiation stages including V(D)J recombination bars (Dik et al., 2005; van Zelm et al., 2005) and genetic defects underlying PID that result in impaired precursor differentiation. Blocks in B-cell development are derived from immunophenotyping studies on bone marrow samples from agammaglobulinemia and SCID patients. Developmental blocks in the T-cell lineage largely rely on data from targeted mutation studies in the mouse.
