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. 2011 Dec 7;2:72. doi: 10.3389/fimmu.2011.00072

Figure 1.

Figure 1

A model for initiation of TCR– CD3 phosphorylation, and the recruitment of the co-receptor. (A) Before TCR interaction with MHCp. Lck and/or Fyn are associated with the plasma membrane, and Lck also exists associated with CD8. Upon TCR binding to MHCp (B) the Fyn and/or non-CD8 bound Lck becomes associated with the TCR–CD3 complex, and phosphorylates CD3ζ ITAMs and then ZAP70 which binds to the phosphorylated CD3ζ ITAMs. (C) The SH2 domain of CD8 bound Lck then interacts with the phospho-ZAP70, pulling CD8 into proximity with the MHCp-interacting TCR. (D) The extracellular immunoglobulin domains then bind to the MHCp, stabilizing the TCR–MHCp interaction.