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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Cancer Res. 2012 Mar 6;72(9):2262–2274. doi: 10.1158/0008-5472.CAN-11-2593

Figure 7.

Figure 7

Schematic representation of Cav1 mediated mechanisms regulating primary melanoma tumor growth and metastasis in mice. In primary melanoma, absence of Cav1 in dermal fibroblasts promotes the growth of B16F10 cells by enhanced expression of protumorigenic cytokines (left). In contrast, absence of Cav1 results in reduced VCAM1/ICAM1 expression levels and in inhibition of transendothelial migration and lung colonization of B16F10 cells (right). FB, dermal fibroblasts; EC, endothelial cells; MM, malignant melanoma; BM, basement membrane.