Table 1.
Animal number | Sex | Age at arrival in our facility (days) | Age at Tx (days) | Start of clinical features (age, days) | Period of IS (age, days) | Survival after Tx (days) | Comments |
---|---|---|---|---|---|---|---|
B4908 | M | 70 | - | - | - | - | No Tx or IS No diarrhea Alive |
B5108 | M | 64 | - | - | - | - | No Tx or IS No diarrhea Alive |
B7507 | M | 67 | 98 | 300 | Anti-CD154 (317) MMF (307) |
324 (Died) | Diarrhea Dehydration Collagenous colitis diagnosed at necropsy |
B5508 | M | 57 | 98 | 125 | Anti-CD154 (137) MMF (132) |
146 (Euthanized) | Diarrhea Dehydration Collagenous colitis diagnosed at necropsy |
B5008 | M | 65 | 107 | 130 | Anti-CD154 (139) MMF (134) |
> (euthanized at 24m, end of follow-up) | Diarrhea Colon biopsy (non-diagnostic) Treatment with budesonide |
B5708 | F | 43 | 87 | 127 | Anti-CD154 (145) MMF (131) |
> (euthanized at 24m, end of follow-up) | Diarrhea Treatment with budesonide |
Anti-CD154 mAb = anti-CD154 monoclonal antibody
IS = immunosuppressive therapy
MMF = mycophenolate mofetil
Tx = transplantation