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Collagenous Colitis in Humans and Baboons: Comparison of Pathology
| Feature | Humans | Baboons |
|---|---|---|
| Gross intestinal lesions | No | No |
| Pathogens associated with disease onset | None | None |
| Collagen deposition | Extensive in colon | Extensive in colon |
| Small intestine involvement | Villous blunting and necrosis | Villous blunting and necrosis |
| Location of collagen deposition | Primarily subepithelial | Primarily submucosal |
| Inflammatory cell infiltrates | Yes; lymphocytes, plasma cells | Minimal |
