Table 1.

Glyoxylate Stetter Substrate Scope^a

Entry	R	Product	% yieldb
1	C6H5	1a	96
2	4Cl-C6H5	1b	95
3	4Me-C6H5	1c	92
4	4MeO-C6H5	1d	93
5	4NC-C6H5	1e	90
6	2Me-C6H5	1f	78
7c	piperonyl	1g	91
8	2-furyl	1h	87
9	3-N-TsIndole	1i	89
10	3-N-BocIndole	1j	84
11	CH2CHPh	1k	93

^aConditions: Unless otherwise noted, all reactions were performed on a 2.0 mmol scale in PhCH₃ (4 mL) at ambient temperature for 16 h.

^bIsolated yield.

^cReaction performed on a 10 mmol scale.