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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Curr Opin Genet Dev. 2011 Dec 12;22(2):79–85. doi: 10.1016/j.gde.2011.11.001

Figure 2. Influence of enhancer-promoter interaction on intra-nuclear migration to a transcription factory.

Figure 2

Before activation a locus occupies a position near the nuclear periphery and the enhancer and promoter do not yet interact with each other. A. In one view, after activation the enhancer interacts with the promoter which in turn leads to locus migration into the nuclear interior and localization in an RNA pol II transcription factory. Subsequently, transcription at the enhancer and promoter produces ncRNA that stabilize the interaction and mRNA respectively. B. Alternatively, the locus migrates to an interior position without communication between the enhancer and the target gene promoter and their interaction is established in the RNA polII factory, possibly with the participation of the ncRNA transcript. Designations are the same as in Figure 1.