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The mechanisms for the induction of LTP. H2S and nitric oxide (•NO) facilitate the induction of hippocampal long-term potentiation (LTP) with different mechanisms. •NO, which is produced from arginine, diffuses to presynapse to activate guanylyl cyclase, leading to the production of cyclic GMP that activates G-kinase to increase the release of a neurotransmitter glutamate. Although H2S does not have any effect on guanylyl cyclase, it enhances the activity of NMDA receptors.
