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The sensitivity of astrocytes to H2S depends on the state of maturation and reactivity. GFAP positive-mature astrocytes and those maturation-induced by leukemia inhibitory factor (LIF) respond well to H2S. In contrast, premature astrocytes as well as reactive astrocytes induced by EGF, TGF-α, cAMP, and interleukin-1β do not respond to H2S.
