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. 2012 Jul 1;17(1):81–94. doi: 10.1089/ars.2011.4358

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Copyright 2012, Mary Ann Liebert, Inc.

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FIG. 8. — Contraction of isolated rat aortic rings with intact (PAAT+, white squares) or removed (PAAT−, black squares) periaortic adipose tissue in response to phenylephrine. On the horizontal axis is presented negative logarithm of phenylephrine (PE) concentration and on the vertical axis percent of contraction induced by PE in comparison to maximal contraction induced by 60 mM KCl. Aortic rings were isolated from control rats (top panel, A) and rats treated with atorvastatin for 3 weeks (bottom panel, B). Intact PAAT reduced contractility in both groups. There was no difference in PE-induced contractility of PAAT− rings between groups; however, contractility of PAAT+ rings was smaller in atorvastatin-treated rats. *p<0.05, **p<0.001 in comparison to contractility of control PAAT+ rings induced by the same PE concentration [reproduced with permission from ref. (72)]. PAAT, periaortic adipose tissue.