Table 2.

Genetic causes of NAFLD

Disease	Genetic mutation	Age of presentation	Other clinical symptoms	Management
Abetalipoproteinemia	Microsomal triglyceride transfer protein	Infancy	Growth problems, mental retardation	Low-fat diet; fat soluble vitamin supplementation
Familial hypobetalipoproteinemia	apoB100	Infancy	Failure to thrive steatorrhea, spinocerebellar degenerative ataxia	Low-fat diet; fat soluble vitamin supplementation
Familial combined hyperlipidemia	USF1	Infancy	Hypertriglyceridemia, hypercholesterolemia,	Low-fat diets, exercise, smoking cessation, weight loss
Glycogen storage disease	PHKA2, PHKB	Infancy	Growth retardation, lactic acidosis, and development delay	Avoidance of fasting, ingestion of corn starch, liver transplantation
Weber–Christian disease	unknown	Childhood	Fever, arthralgias, myalgias, skin lesions, and painful subcutaneous nodules	Immunosuppressive reagents, NSAIDs, glucocorticoids
Lipodystrophy (congenital)	AGPAT2, BSCL2	Infancy	Severe fat loss, voracious appetite, accelerated linear growth, and advanced bone age	Low-fat diet

NAFLD, nonalcoholic fatty liver disease; NSAID, nonsteroidal anti-inflammatory drug