Figure 3. Effects of monocyte depletion on the course of NSV encephalitis in wild-type mice.

Treatment with clodronate-loaded liposomes effectively prevents CNS infiltration of CD45^high circulating monocytes on day 6 of NSV encephalitis compared with PBS-loaded liposomes (A, B). Dot plots show staining when gated on CD11b+ cells only. Systemic depletion of these cells has no effect on the outcome of NSV encephalitis (C). Data are representative of two separate experiments performed under identical conditions.