Table 1.
CTLm epitopes (and synthesized epitope variant peptides) identified in EIAVWSU5-infected horses A2140, A2147, A2150, and A2153
| CTLm epitope designation (abbreviated) | No. of aa | aa Sequence | ELA-A restriction | EIAV protein (aa positions) | Overall avidity (nM) | Synthesized variant peptide designation (abbreviated) | Synthesized variant peptide aa sequence | Horse | Progressor/nonprogressor |
|---|---|---|---|---|---|---|---|---|---|
| Env195–206RW12 Env-RW12 |
12 | RVEDVTNTAEYW | A1 | Env 195–206 | 0.21 | Env195–206HW12v Env-HW12v |
HVKDETNTTEYW | A2140 | Progressor |
| Gag21–32GW12 Gag-GW12 |
12 | GSQKLTTGNCNW | A1 | Gag 21–32 | 155 | None assigned | GSQKLSTGNCNW GSQKLNTGNCNW |
A2140 | Progressor |
| Gag288–297FK10 Gag-FK10 |
10 | FVDRLLSQIK | A4 | Gag 288–297 | 18.7 | None | None | A2147 | Progressor |
| Rev57–67QW11 Rev-QW11 |
11 | QAEVLQERLEW | A1 | Rev 57–67 | 0.29 | None | None | A2150 | Nonprogressor |
| Rev120–131PR12 Rev-PR12 |
12 | PRVLRPGDSKRR | A1 | Rev 120–131 | 5658 | None synthesized | None synthesized | A2150 | Nonprogressor |
| Rev24–33R10 Rev-IR10 |
10 | IPSQTCITRR | Not determined | Rev 24–33 | 47.8 | None synthesized | None synthesized | A2153 | Nonprogressor |
| Rev104–112GR9 Rev-GR9 |
9 | GGYQRAQER | Not determined | Rev 104–112 | 25.1 | None synthesized | None synthesized | A2153 | Nonprogressor |