Table 3.
Ratio of TLR2/TLR4 chemokine responsesa.
| Sham | Burn | |||||
|---|---|---|---|---|---|---|
| Day 1 | Day 3 | Day 7 | Day 1 | Day 3 | Day 7 | |
| KC | 1.19±0.11b | 1.76±0.17c | 1.60±0.23 | 1.11±0.53 | 1.15±0.18d | 1.08±0.08d |
| MIP-1α | 1.93±0.57 | 2.66±0.44 | 1.59±0.10 | 2.47±0.43 | 2.30±0.73 | 0.97±0.08d |
| MIP-1β | 1.19±0.22 | 1.55±0.15 | 1.44±0.17 | 1.26±0.14 | 1.37±0.30 | 1.19±0.91 |
| RANTES | 0.23±0.03c | 0.30±0.05c | 0.26±0.05c | 0.30±0.07c | 0.30±0.11c | 0.21±0.04c |
a
The ratio of the TLR2 (zymosan) chemokine response to that of the TLR4 (LPS) response was determined for each culture as an index of the relative TLR response for each cytokine. A ratio of 1.0 indicates comparable TLR2 and TLR4 responses; a ratio < 1.0 indicates a stronger TLR4 response and; a ratio > 1.0 indicates a stronger TLR2 response. All data was log transformed prior to analysis due to non-normal distribution;
b
Data are expressed as mean ± SE for 4-10 mice/group;
c
p<0.05 as compared with 1.0;
d
p<0.05 as compared with respective sham value