Figure 3.

Survival curves for the association between macrolide use and successful discontinuation of mechanical ventilation at 28 days. Cox proportional hazards model adjusted for age, Simplified Acute Physiology II Score, duration of ICU stay prior to study enrollment, tidal volume randomization group, presence of pneumonia, and presence of sepsis. Use of a macrolide antibiotic was associated with a significant increase in the likelihood of achieving successful discontinuation of mechanical ventilation (hazard ratio, 1.93; 95% CI, 1.18-3.17; P = .009).