Table 2.
—Baseline Characteristics of Study Cohort Stratified by Fluoroquinolone Exposure
| Variable | Fluroquinolone (n = 90) | No Fluoroquinolone (n = 145) | P Value |
| Age, y | 51 ± 17 | 51 ± 17 | .98 |
| Sex, male | 47 (52) | 98 (68) | .02a |
| Race, white | 71 (79) | 108 (75) | .53 |
| BMI, kg/m2 | 28.6 ± 8.3 | 27.9 ± 7.1 | .88 |
| Primary ALI risk factor | |||
| Pneumonia | 39 (43) | 45 (31) | .07a |
| Sepsis | 25 (28) | 33 (23) | .43 |
| Aspiration | 12 (13) | 26 (18) | .47 |
| Trauma | 5 (6) | 17 (12) | .17 |
| Multiple transfusions | 1 (1) | 5 (3.5) | .41 |
| Other | 8 (9) | 19 (13) | .40 |
| SAPS II | 50.7 ± 15.7 | 45.6 ± 14.2 | .02a |
| Brussels Organ Failure Score | 2.0 ± 1.11 | 1.70 ± 0.94 | .05a |
| Comorbidities | |||
| Diabetes | 15 (17) | 27 (19) | .73 |
| AIDS | 5 (6) | 9 (6) | 1.0 |
| Metastatic or hematologic malignancy | 7 (8) | 7 (5) | .40 |
| End-stage renal failure/dialysis | 3 (3) | 1 (0.7) | .16 |
| Radiographic lung injury score | 3.71 ± 0.55 | 3.70 ± 0.61 | |
| Tidal volume, mg/kg of IBW | 10.4 ± 2 | 10 ± 2 | .19 |
| Pao2/Fio2 | 144 ± 73 | 146 ± 62 | .36 |
| PEEP, cm H2O | 8.8 ± 4.3 | 9.1 ± 4.0 | .38 |
| Pplat, cm H2O | 30 ± 10 | 30 ± 7.8 | .48 |
| Peak pressure, cm H2O | 37 ± 12 | 36.8 ± 8.8 | .85 |
| Paco2, mm Hg | 35 ± 10 | 37 ± 8.1 | .14 |
| Arterial pH | 7.39 ± 0.09 | 7.41 ± 0.07 | .31 |
| Minute ventilation, L/min | 13.5 ± 4.2 | 12.7 ± 3.72 | .18 |
| Duration of intubation prior to enrollment, median (IQR), d | 1 (0-1) | 1 (1-2) | .02a |
| Duration of ICU stay prior to enrollment, median (IQR), d | 1 (1-2) | 1 (1-2) | .05a |
| Duration of hospitalization prior to enrollment, median (IQR), d | 2 (1-5) | 2 (1-4) | .32 |
| Randomized to low tidal volume | 52 (58) | 83 (57) | 1.0 |
| Randomized to lisofylline | 47 (52) | 69 (48) | .51 |
Continuous variables are presented as mean ± SD and categorical variables are presented as No. (%) unless indicated otherwise. See Table 1 legend for expansion of abbreviations.
a
P < .1 and consideration for inclusion in multivariable model.