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. Author manuscript; available in PMC: 2012 May 3.
Published in final edited form as: Nature. 2011 Sep 11;477(7365):424–430. doi: 10.1038/nature10495

Figure 4. IGCR1 is required to allow feedback regulation of proximal VH to DJH recombination.

Figure 4

(a) Mean percentage of splenic B cells with VHDJH rearrangements on both IgH alleles as determined by analyses of hybridomas from three independent sets of WT, IGCR1+/-, and IGCR1-/- mice (Supp. Table 5). Error bars represent standard deviation. p-values were calculated by student t-test. (b) IgH VHDJH rearrangements in splenic B cells from two independent WT and VB1-8 knock-in mice carrying either a WT (IGCR1+/+ VB1-8 KI) or an IGCR1 deleted (IGCR1+/- VB1-8 KI) second allele. Bands corresponding to rearrangements to various JHs are indicated on right. DLG5 is the loading control.