Table 1.

Types of anti-pro-atherothrombogenic molecules in endothelium

	Anti-atherothrombogenic Mediators	Pro-atherothrombogenic Mediators
Cell Surface Molecules	Thrombomodulin Protein C Heparin and Heparan sulfate Ectonucleotidases Tissue Factor Pathway Inhibitor Endothelial Estrogen Receptor-alpha (ERα)	Tissue Factor Binding Sites for coagulation factors
Released Molecules	Nitric Oxide Prostacyclin Tissue Plasminogen Activator (t-PA) t-PA binding sites	Thromboxane A2 Platelet Activating Factor Von Willebrand Factor Endothelin

ERα plays key role in the E2-induced prevention of endothelial dysfunction after ischemia/reperfusion (60)