Figure 6.

Classification of treated and untreated CTCL and psoriasis from mouse xenograft models. (A) PCA plot of all samples from mouse xenograft CTCL model (green), and psoriasis model (orange), based on the 5-miRNA profile. Solid bars indicate vehicle controls, whereas hatched green bars indicate systemic treatment with a COX-2 inhibitor (celecoxib) and hatched orange bars indicate topical treatment with steroid (betamethasone). (B) Classification performance in the mouse xenograft set using the trained 5-miRNA classifier. (C) Bar plots showing normalized log₂ expression levels relative to average of lowest expressions measured across all samples. Error bars denote ± 1 SD. For each miRNA, P values were calculated using a t test between treated and untreated samples from each model, respectively.