Table 1. Pathological conditions and injuries, their effects on adhesion and their correlations with CNV.
Context | Adhesion | Effects | ||||||
Condition | Subject | RPE-RPE | RBaM-BrM | RPE-POS | RPE Viability | CNV Loci | Simulation Results | |
1 | Normal Aging (No Drusen) | Human | + | + | + | + | - | No initiation even in presence of small holes in BrM (Table S1) |
2 | Hard Drusen [23], [35] | Human | − | − | + | − | - | See the Current Hypotheses for CNV Initiation and Progression section |
3 | Soft Drusen [23], [35]–[37] | Human | −/+ | −/− | −/+ | −/+ | Sub-RPE | S11, T12, P13 CNV (Tables S2, S5, S6, S7) |
4 | Sub-retinal Drusenoid (reticular pseudodrusen) [44], [45], [96] | Human | −/− | −/−/+ | −/− | −/+ | Sub-Retinal and/or Sub-RPE | T12, S22, P23 CNV (Tables S6, S8, S9) |
5 | BrM Calcification [23], [24] | Human | −/+ | −/+ | + | −/+ | * | * |
6 | Active Inflammation [80] | Young Human | − | + | −/−/+ | −/+ | Sub-Retinal | S22 CNV (Table S8) |
7 | Retinal Detachment [14], [40] | Cat | −/− | + | − | + | * | S22 CNV (Table S8) |
8 | High Fat Diet+Aging+Blue Light [75] | Mouse | −/+ | −/− | + | +/− | Early Sub-RPE | ET1 CNV (Table S2) |
9 | Chemotoxicity [81] | Rabbit | − | −/+ | − | − | Sub-Retinal | P23 CNV (Table S9) |
10 | Sub-Retinal Injection [83]–[86] | Rat, Rabbit | − | −/+ | − | −/+ | Sub-Retinal | S22, P23 CNV (Tables S8, S9) |
11 | Sub-retinal Injection and VEGF Overexpression [13] | Rat | − | −/+ | − | −/+ | Sub-Retinal | S22, P23 CNV (Tables S8, S9) |
Columns: Condition: type of condition, injury or perturbation in clinical or experimental observations. Subject: human or animal. Adhesion: strength of adhesion (+ = normal, − = moderately impaired, − = severely impaired). Effects: RPE viability (+ = most RPE cells remain viable, − = some RPE cells die, − = most RPE cells die), CNV loci (− = no or low probability of initiation and progression, sub-RPE = Type 1, sub-retinal = Type 2, combined pattern = Type 3, * = no data presented/available). Simulation results (boldface words = model objects. CNV Type definitions: see Table 4 and Table 5. * = no data presented/available. See the Results and Discussion sections for details of simulation results).