Table 1. Pathological conditions and injuries, their effects on adhesion and their correlations with CNV.

	Context		Adhesion			Effects
	Condition	Subject	RPE-RPE	RBaM-BrM	RPE-POS	RPE Viability	CNV Loci	Simulation Results
1	Normal Aging (No Drusen)	Human	+	+	+	+	-	No initiation even in presence of small holes in BrM (Table S1)
2	Hard Drusen [23], [35]	Human	−	−	+	−	-	See the Current Hypotheses for CNV Initiation and Progression section
3	Soft Drusen [23], [35]–[37]	Human	−/+	−/−	−/+	−/+	Sub-RPE	S11, T12, P13 CNV (Tables S2, S5, S6, S7)
4	Sub-retinal Drusenoid (reticular pseudodrusen) [44], [45], [96]	Human	−/−	−/−/+	−/−	−/+	Sub-Retinal and/or Sub-RPE	T12, S22, P23 CNV (Tables S6, S8, S9)
5	BrM Calcification [23], [24]	Human	−/+	−/+	+	−/+	*	*
6	Active Inflammation [80]	Young Human	−	+	−/−/+	−/+	Sub-Retinal	S22 CNV (Table S8)
7	Retinal Detachment [14], [40]	Cat	−/−	+	−	+	*	S22 CNV (Table S8)
8	High Fat Diet+Aging+Blue Light [75]	Mouse	−/+	−/−	+	+/−	Early Sub-RPE	ET1 CNV (Table S2)
9	Chemotoxicity [81]	Rabbit	−	−/+	−	−	Sub-Retinal	P23 CNV (Table S9)
10	Sub-Retinal Injection [83]–[86]	Rat, Rabbit	−	−/+	−	−/+	Sub-Retinal	S22, P23 CNV (Tables S8, S9)
11	Sub-retinal Injection and VEGF Overexpression [13]	Rat	−	−/+	−	−/+	Sub-Retinal	S22, P23 CNV (Tables S8, S9)

Columns: Condition: type of condition, injury or perturbation in clinical or experimental observations. Subject: human or animal. Adhesion: strength of adhesion (+ = normal, − = moderately impaired, − = severely impaired). Effects: RPE viability (+ = most RPE cells remain viable, − = some RPE cells die, − = most RPE cells die), CNV loci (− = no or low probability of initiation and progression, sub-RPE = Type 1, sub-retinal = Type 2, combined pattern = Type 3, * = no data presented/available). Simulation results (boldface words = model objects. CNV Type definitions: see Table 4 and Table 5. * = no data presented/available. See the Results and Discussion sections for details of simulation results).